Red blood cell alloimmunization in sickle cell disease: listen to your ancestors.

Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management.

Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk fac...

Delayed Hemolytic Transfusion Reaction in Sickle Cell Disease

Patients with sickle cell disease frequently require red blood cell transfusions . However, transfusions can cause delayed hemolytic transfusion reaction (DHTR), a serious and potentially life-threatening complication of alloimmunization that results in hemolysis of transfused as well as patients’ own red cells . Although we are beginning to understand some of the pathophysiology and risk facto...

The prevention and management of alloimmunization in sickle cell disease: the benefit of extended phenotypic matching of red blood cells.

Pattern of chronic lung lesions in adults with sickle cell disease in Lagos, Nigeria

Background: The vascular response to recurrent tissue hypoxia and reperfusion following red blood cell sickling causes acute chest syndrome and chronic lung disease. The purpose of this study was to determine the pattern of chronic lung lesions and possible risk factors in sickle cell patients in lagos, Nigeria.Methods: From July 2012 to April 2013, Pulmonary function test (PFT) and chest-x-ray...

Antioxidant Enzymes and Acute Phase Proteins Correlate with Marker of Lipid Peroxide in Adult Nigerian Sickle Cell Disease Patients

Objective(s) Sickle cell disease is a genetic disorder characterized by chronic haemolytic anaemia. Haemoglobin S containing red blood cells may be susceptible to oxidative stress due to imbalance between production of reactive oxygen species and the countering effect of the various antioxidants present in the body. Materials and Methods We evaluated some antioxidant enzymes which include gl...